Eigene Publikationen zu dem Thema Sepsis mit externen Links zur Kurzform des jeweiligen Artikels

  1. Clemens Möller, Lena Heinbockel, Patrick Garidel, Thomas Gutsmann, Karl Mauss, Günther Weindl, Satoshi Fukuoka, Dominik Loser, Timm Danker, Klaus Brandenburg.Toxicological and Safety Pharmacological Profiling of the Anti-Infective and Anti-Inflammatory Peptide Pep19-2.5 (2022 Dec 06) https://pubmed.ncbi.nlm.nih.gov/36557665/
  2. Rima El-Dirany, Celia Fernández-Rubio, José Peña-Guerrero, Esther Moreno, Esther Larrea, Socorro Espuelas, Fadi Abdel-Sater, Klaus Brandenburg, Guillermo Martínez-de-Tejada, Paul Nguewa, Repurposing the Antibacterial Agents Peptide 19-4LF and Peptide 19-2.5 for Treatment of Cutaneous Leishmaniasis (2022 Nov 20). https://pubmed.ncbi.nlm.nih.gov/36432719
  3. Jiarui Li, Guillem Prats-Ejarque, Marc Torrent, David Andreu, Klaus Brandenburg, Pablo Fernández-Millán, Ester Boix. In Vivo Evaluation of ECP Peptide Analogues for the Treatment of Acinetobacter baumannii Infection (2022 Feb 20) https://pubmed.ncbi.nlm.nih.gov/35203595/
  4. Shireen Mohammad, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S D Purvis, Giuseppe Danilo Norata, Andrea Baragetti, Alberico Luigi Catapano, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M Coldewey, Massimo Collino, Muhammad M Yaqoob, Lukas Martin, Christoph Thiemermann. A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice (2021 Jul 19) https://pubmed.ncbi.nlm.nih.gov/34349763/
  5. Lena Heinbockel, Günther Weindl, Wilmar Correa, Julius Brandenburg, Norbert Reiling, Karl-Heinz Wiesmüller , Tobias Schürholz, Thomas Gutsmann, Guillermo Martinez de Tejada, Karl Mauss and Klaus Brandenburg, Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5. IJMS 2021, 22, 1465. https://pubmed.ncbi.nlm.nih.gov/33540553
  6. Rima El-Dirany , Hawraa Shahrour , Zeinab Dirany , Fadi Abdel-Sater , Gustavo G, BiomoleculesRima El-Dirany, Klaus Brandenburg , Guillermo Martinez de Tejada and Paul A. Nguewa Activity of Anti-Microbial Peptides (AMPs) against Leishmania and Other Parasites: An Overview Biomolecules 2021, 11, 984. https://doi.org/10.3390/biom11070984
  7. Andra B. Schromm, Laura Paulowski, Yani Kaconis , Franziska Kopp, Max Koistinen , Annemarie Donoghue , Susanne Keese, Christian Nehls , Julia Wernecke, Patrick Garidel, Eva Sevcsik, Karl Lohner, Thomas Gutsmann. Sanchez-Gomez, Guillermo Martinez-de-Tejada, Klaus Brandenburg, Thomas Gutsmann. Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes, PNAS 2021 Vol. 118 No. 27 e2101721118, https://www.pnas.org/content/118/27/e2101721118
  8. Sabrina Wohlfart, Michael Kilian, Philip Storck, Thomas Gutsmann, Klaus Brandenburg and Walter Mier. Mass Spectrometric Quantification of the Antimicrobial Peptide Pep19-2.5 with Stable Isotope Labeling and Acidic Hydrolysis. Pharmaceutics 2021, 13, 1342, https://pubmed.ncbi.nlm.nih.gov/34575418
  9. Philip Storck, Florian Umstätter, Sabrina Wohlfart, Cornelius Domhan, Christian Kleis, Julia Werner, Klaus Brandenburg, Stefan Zimmermann, Uwe Haberkorn, Walter Mier, Philipp Uhl, Fatty Acid Conjugation Leads to Length-Dependent Antimicrobial Activity of a Synthetic Antibacterial Peptide (Pep19-4LF) 2020. https://doi.org/10.3390/antibiotics9120844
  10. N. Kuhlmann Nicole Kuhlmann, Christian Nehls , Lena Heinbockel, Wilmar Correa, Ralf Moll, Thomas Gutsmann, Christian Hübner, Uwe Englisch and Klaus Brandenburg. Encapsulation and release of Aspidasept peptides in polysaccharide formulation for oral application et al, Eur. J. Pharm. Sci. (2020) https://pubmed.ncbi.nlm.nih.gov/33359480
  11. Brandenburg K, Schromm AB, Weindl G, Heinbockel L, Correa W, Mauss K, Martinez de Tejada G, Garidel P.Expert Rev Anti Infect Ther. An update on endotoxin neutralization strategies in Gram-negative bacterial infections. 2021 Apr;19(4):495-517. doi: 10.1080/14787210.2021.1834847. Epub 2020 Nov 19.PMID: 33210958 https://pubmed.ncbi.nlm.nih.gov/33210958
  12. Judith Thoma, Wasim Abuillan, Ippei Furikado, Taichi Habe, Akihisa Yamamoto, Simone Goerlich, Stefan Kaufmann, Klaus Brandenburg, Thomas Gutsmann, Oleg Konovalov, Shigeto Inoue, Motomu Tanaka “Specific Localisation of Ions in Bacterial Membranes Unravels Physical Mechanism of Effective Bacteria Killing by Sanitiser”. Sci Rep.2020 Jul 23;10(1):12302 https://www.nature.com/articles/s41598-020-69064-1
  13. L. Subh, W. Correa T.‐J. Pinkvos P. Behrens K. Brandenburg T. Gutsmann M. Stiesch K. Doll A. Winkel. Synthetic anti‐endotoxin peptides interfere with Gram‐positive and Gram‐negative bacteria, their adhesion and biofilm formation on titanium J. Appl. Microbiol. 129, 71-726 (2020) https://pubmed.ncbi.nlm.nih.gov/32403180/
  14. Correa W , Brandenburg J, Behrends J, Heinbockel L, Reiling N, Paulowski L, Schwudke D, Stephan K, Martinez-de-Tejada G, Brandenburg K, Gutsmann T. Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides. Biophys. J. 2019 Nov 19;117(10):1805-1819 https://pubmed.ncbi.nlm.nih.gov/31676134/
  15. Correa W, Heinbockel L, Behrends J, Kaconis Y, Barcena mit: Varella S, Gutsmann T, Mauss K, Schürholz T, Schromm AB, Martinez de Tejada G, Brandenburg K. Antibacterial action of synthetic anti-lipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins. FEBS J. 2019 Mar 7. doi: 10.1111/febs.14805. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/30843356
  16. Jannadi H, Correa W, Zhang Z, Brandenburg K, Oueslati R, Rouabhia M. Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation.  Microb Pathog. 2019 May 18;133:103546. Loi: 10.1016/j.micpath.2019.103546. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31112769
  17. W. Correa, L. Heinbockel, G. Martinez de Tejada, S. Sanchez, P. Garidel, T. Schürholz, W. Mier. M.Hornef, T. Gutsmann,  K. Mauss, G. Weindl, and K. Brandenburg, Synthetic anti-lipopolysaccharide peptides (SALP) as effective inhibitors of pathogen-associated molecular patterns (PAMPs), in Antimicrobial Peptides, Basics for Clinical Application, Katsumi Matsuzaki (Ed.) , Chapter 8, pp. 111-130, Springer-Verlag 2019. https://www.ncbi.nlm.nih.gov/pubmed/30980356
  18. K. Brandenburg, W. Correa, L. Heinbockel, K.-H. Wiesmüller, T. Schürholz, G. Weindl, K. Mauss, G. Martinez, and P. Garidel, Development of antimicrobial peptides based on Limulus anti-lipopolysaccharide factor, in Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems, Ed. K.L. Wiiliams, Chapter 19, Springer-Verlag 2019
  19. Pfalzgraff A, Correa W, Heinbockel L, Schromm AB, Lübow. C., Gisch N, Martinez-de-Tejada G, Brandenburg K, Weindl G, LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses. Biochim Biophys Acta Mol Cell Biol Lipids. 2019Oct;1864(10):1503-1513 https://www.ncbi.nlm.nih.gov/pubmed/31163264
  20. Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5. Heinbockel L, Weindl G, Martinez-de-Tejada G, Correa W, Sanchez-Gomez S, Bárcena-Varela S, Goldmann T, Garidel P, Gutsmann T, Brandenburg K. Front Immunol. 2018 Jul 26;9:1704. doi: 10.3389/fimmu.2018.01704. eCollection 2018. Review. PMID: 30093904 https://www.ncbi.nlm.nih.gov/pubmed/?term=30093904
  21. A. Pfalzgraff, Bárcena-Varela S, Heinbockel L, Gutsmann T, Brandenburg K, Martinez-de-Tejada G, Weindl G.Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo. British Journal of Pharmacology175, 2018:3581-3593. https://www.ncbi.nlm.nih.gov/pubmed/29947028
  22. Khatri I, Alexander C, Brandenburg K, Chen Z, Heini A, Heumann D, Mach JP, Mazzoli V, Rietschel E, Tersikh A, Ulmer A, Yu K, Zähringer U, Gorczynski R. Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression. Pharmacogenomics J. 2018 Jan 4. doi: 10.1038/s41397-017-0008-y. https://www.ncbi.nlm.nih.gov/pubmed/29302041
  23. Kuhlmann N, Heinbockel L, Correa W, Gutsmann T, Goldmann T, Englisch U, Brandenburg K. Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation. Eur J Pharm Sci. 2018 Mar 30;115:240-247 219) https://www.ncbi.nlm.nih.gov/pubmed/29337217
  24. Pfalzgraff A, Brandenburg K, Weindl G. Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds.Front Pharmacol. 2018 Mar 28;9:281. doi: 10.3389/fphar.2018.00281. eCollection 2018. https://www.ncbi.nlm.nih.gov/pubmed/29337217
  25. Correa W, Brandenburg K, Zähringer U, Ravuri K, Khan T,von Wintzingerode F. Biophysical Analysis of Lipopolysaccharide Formulations for an Understanding of the Low Endotoxin Recovery (LER) Phenomenon. Int J Mol Sci. 2017 Dec 16;18(12). pii: E2737. doi: 10.3390/ijms18122737. https://www.ncbi.nlm.nih.gov/pubmed/?term=ijms18122737
  26. Gorczynski RM, Alexander C, Brandenburg K, Chen Z, Heini A, Neumann D, Mach JP, Rietschel ET, Tersikh A, Ulmer AJ, Yu K, Zäringer U, Khatri I. An altered REDOX environ ent, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression. Int. Immunopharmacol. 50 (2017) 69-76
  27. Ito H, Murakami R, Sakuma S, Tsai CD, Gutsmann T, Brandenburg K, Pöschl JM, Arai F, Kaneko M, Tanaka M. Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling. Sci Rep. 2017 Feb 24;7:43134. doi: 10.1038/srep43134. https://www.ncbi.nlm.nih.gov/pubmed/28233788
  28. Yamada N, Martin LB, Zechendorf E, Purvis GS, Chiazza F, Varrone B, Collino M, Shepherd J, Heinbockel L, Gutsmann T, Correa W, Brandenburg K, Marx G, Schuerholz T, Brohi K, Thiemermann C. Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Ann Surg. 2017 Mar 10. doi: 10.1097/SLA.0000000000002186. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28288070
  29. Pfalzgraff A, Heinbockel L, Su Q, Brandenburg K, Weindl G. Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses. Biochem Pharmacol. 2017 Sep 15;140:64-72. doi: 10.1016/j.bcp.2017.05.015. Epub 2017 May 21. https://www.ncbi.nlm.nih.gov/pubmed/28539262
  30. Sergio Bárcena-Varela1, Guillermo Martínez-de-Tejada1, Lukas Martin2, Tobias Schuerholz3, Ana Gloria Gil-Royo4, Satoshi Fukuoka5, Torsten Goldmann6,7, Daniel Droemann7,8, Wilmar Correa9, Thomas Gutsmann9, Klaus Brandenburg9* and Lena Heinbockel. Coupling killing to neutralization: Combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits. Experim. & Molec., Medicine (2017) Jun 16;49(6):e345. doi: 10.1038/emm.2017.75. https://www.ncbi.nlm.nih.gov/pubmed/28620220
  31. L. Martin, K. Horst, F. Chiazza, S. Oggero, M. Collino, K. Brandenburg, F. Hildebrand3, G. Marx, C. Thiemermann, T. Schuerholz. The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Sci. Rep 2016 6:37277 | DOI: 10.1038/srep37277 https://www.ncbi.nlm.nih.gov/pubmed/27853260
  32. Malgorzata-Miller G, Heinbockel L, Brandenburg K, van der Meer JW, Netea MG, Joosten LA. Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications. Sci Rep. 2016 Sep 27;6:34221. doi: 10.1038/srep34221. https://www.ncbi.nlm.nih.gov/pubmed/27670746
  33. Pfalzgraff A, Heinbockel L, Su Q, Gutsmann T, Brandenburg K, Weindl G. Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration. Sci Rep. 2016 Aug 11;6:31577. doi: 10.1038/srep31577. https://www.ncbi.nlm.nih.gov/pubmed/27509895
  34. Marcela Manrique-Moreno, Lena Heinbockel, Mario Suwalsky, Patrick Garidel, Klaus Brandenburg. Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserinebilayer membranes. Biochim. Biophys. Acta 1858 (2016) 2123–2131. https://www.ncbi.nlm.nih.gov/pubmed/27316371
  35. Brandenburg K, Heinbockel L, Correa W, Fukuoka S, Gutsmann T, Zähringer U, Koch M.H.J. Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5. J Struct Biol. 2016 Apr;194(1):68-77. doi: 10.1016/j.jsb.2016.01.014. Epub 2016 Jan 29. http://www.ncbi.nlm.nih.gov/pubmed/26828112
  36. Ulmer AJ, Kaconis Y, Heinbockel L, Correa W, Alexander C, Rietschel ET, Mach JP, Gorczynski RM, Heini A, Rössle M, Richter W, Gutsmann T, Brandenburg K. Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A. Innate Immunity 2016 Apr;22(3):168-80. doi: 10.1177/1753425916632304. Epub 2016 Feb 25 http://www.ncbi.nlm.nih.gov/pubmed/26921253
  37. Brandenburg K, Heinbockel L, Correa W, Lohner K. Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis. Biochim Biophys Acta. 2016, 2736(16)3000, 1-3. http://www.ncbi.nlm.nih.gov/pubmed/26801369
  38. Martin L, De Santis R, Koczera P, Simons N, Haase, Heinbockel L, Brandenburg K, Marx G, Schuerholz T. The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis. PLoS One. 2015 Nov 23;10(11):e0143583. doi: 10.1371/journal.pone.0143583. eCollection 2015. http://www.ncbi.nlm.nih.gov/pubmed/26600070
  39. Dupont A, Heinbockel L, Brandenburg K, Hornef MW. Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa. Gut Microbes. 2014;5(6):761-765 (2014).
  40. Dupont A, Kaconis Y, Yang I, Albers T, Woltemate S, Heinbockel L, Andersson M, Suerbaum S, Brandenburg K, Hornef MW. Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide. Gut 64(2):222-232 (2015).
  41. Zuzuarregui A, Souto D, Pérez-Lorenzo E, Arizti F, Martínez de Tejada G, Moriyón I, Brandenburg K, Arana S, Mujika M. Novel integrated and portable endotoxin detection system based on an electrochemical biosensor. Analyst 140, 654-660 (2015).
  42. Sandetskaya N, Engelmann B, Brandenburg K, Kuhlmeier D. Application of immobilized synthetic anti-lipopolysaccharide peptides for the isolation and detection of bacteria. Eur J Clin Microbiol Infect Dis DOI 10.1007/s10096-015-2399-51 (2015)
  43. Ito H, Kuss N, Rapp BE, Ichikawa M, Gutsmann T, Brandenburg K, Poeschl JM, Tanaka M. Quantification of the Influence of Endotoxins on the Mechanics of Adult and Neonatal Red Blood Cells. J Phys Chem B. (2015) May 29. [Epub ahead of print]
  44. Brandenburg K, Schürholz T, Lack of new antiinfective agents: Passing into the pre-antibiotic age? World J. Biol. Chem. 2015 6(3):71-77.
  45. Martin L,, Schmitz S, De Santis R, Doemming S, Haase H, Hoeger J, Heinbockel L, Brandenburg K, Marx G, Schuerholz T. Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum. PLOS one 10 (2015)
  46. Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T, Gutsmann T, Mie W, Schürholz T, Drömann D, Brandenburg K, Martinez de Tejada G. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. PLOS one, July 21, 2015, DOI: 10.1371.
  47. Martinez de Tejada G, Heinbockel L, Ferrer-Espada R, Heine H, Alexander C, Bárcena-Varela S, Goldmann T, Correa W, Wiesmüller K-H, Gisch N, Sánchez-Gómez S, Fukuoka S, Schürholz T, Gutsmann T, Brandenburg K. Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides. Sci Rep. 22 Sept.2015.
  48. Garidel P, Kaconis Y, Heinbockel L,Wulf M, Gerber S, Munk A, Vill V, Brandenburg K. Self-Organisation, Thermotropic and Lyotropic Properties of Glycolipids Related to their Biological Implications. The Open Biochemistry Journal, 2015, 9, 49-72.
  49. Heinbockel L, Martinez de Tejada G, Sánchez-Gómez S, Kaconis Y, Krause E, Brune W, Schmeiser S, Moennig V, Schürholz T, Dömming S, Hornef M, Dupont A, Hauber J, Garidel P, Schittl B, Lucifora J, Gutsmann T, Krepstakies M, Protzer U, Brandenburg K (2014). Anti-infective Polypeptides for Combating Bacterial and Viral Infections. Frontiers in Clinical Drug Research-Anti-Infectives. Vol.1, in press.
  50. Correa W, Manrique-Moreno M, Patiño E, Peláez-Jaramillo C, Kaconis Y, Gutsmann T, Garidel P, Heinbockel L, Brandenburg K. Galleria mellonella native and analogue peptides Gm1 and ΔGm1.I) Biophysical characterization of the interaction mechanisms with bacterial model membranes. Biochim. Biophys. Acta 1838, 2728-2736 (2014).
  51. Correa W, Manrique-Moreno M, Behrends J, Patiño E, Marella C, Peláez-Jaramillo C, Garidel P, Gutsmann T, Brandenburg K, Heinbockel L. Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) Anti-bacterial and anti-endotoxic effects. Biochim. Biophys. Acta 1838, 2739-2744 (2014)
  52. Heinbockel L, Palacios-Chaves L, Alexander C, Rietschel E, Behrends J, Correa W, Fukuoka S, Gutsmann T, Ulmer AJ, Brandenburg K. Mechanism of Hbγ-35-induced an increase in the activation of the human immune system by endotoxins. Innate Immunity Jul 16, (2014)
  53. Gries A, Prassl R, Fukuoka S, Rössle M, Kaconis Y, Heinbockel L, Gutsmann T, Brandenburg K. Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide. FEBS Open Bio. 2014 May 2;4:432-40. doi: 10.1016/j.fob.(2014).
  54. Hoffmann J, Schneider C, Heinbockel L, Brandenburg K, Reimer R, Gabriel G, A new class of synthetic anti-lipopolysaccharide peptides inhibits Influenza A virus replication by blocking cellular attachment. Antiviral Res. 2014 (in press).
  55. Schurholz T, Heinbockel L, Martinez de Tejada G, . Hornef M, Marx G, and Brandenburg K. Neue Sepsistherapie am Horizont: Antiinflammatorische Peptide.
    DIVI 4: 0144–0152 (2013).
  56. Keese SP, Brandenburg K, Roessle M, Schromm AB. Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages. Innate Immun 2013, Pub ahead of print.
  57. Sil D, Heinbockel L, Kaconis Y, Rössle M, Garidel P, Gutsmann T, David SA, Brandenburg K.. Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines. Open Biochem. J. 7, 83-93 (2013).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  58. Abuillan W, Schneck E, Körner A, Brandenburg K, Gutsmann T, Gill T,
    Vorobiev A, Konovalov O, Tanaka M. Physical interactions of fish protamine and antisepsis peptide drugs with bacterial membranes revealed by combination of specular x-ray reflectivity and grazing-incidence x-ray fluorescence. Phys Rev E Stat Nonlin Soft Matter Phys. 88(1-1):012705. Epub (2013).
  59. Schuerholz T, Doemming S, Hornef M, Martin L, Simon T.-P.,Heinbockel L, Brandenburg K, and Marx G: The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study. Critical Care, 17:R3 (2013)
  60. Richter W, Heinbockel L, Kaconis Y, Steiniger F, Brade L, and Brandenburg K. Cellular distribution of lipid A and LPS R595 after in vitro application to isolated human monocytes by freeze-fracture replica immunogold-labelling. nnate Immun 19 (6) 585 – 592 (2013)
  61. Heinbockel L, Sánchez-Gómez S, Martinez de Tejada G, Dömming S, Brandenburg J, Kaconis Y, Hornef M, Dupont A, Marwitz S, Goldmann T, Ernst M, Gutsmann T, Schürholz T, and Brandenburg K. Broad-Spectrum Neutralizing Activity of Peptide Pep19-2.5 on Bacterial Pathogenicity Factors. Antim.Agents Chemother. 57(3):1480-1487 (2013).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  62. Conde-Álvarez R, Arce-Gorvel V, Iriarte M, Manček-Keber M, Barquero-Calvo E, Palacios-Chaves L, Chacón-Díaz C, Chaves-Olarte E, Martirosyan A, von Bargen K, Grilló MJ, Jerala R, Brandenburg K, Llobet E, Bengoechea JA, Moreno E, Moriyón I, Gorvel JP. The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. PLoS Pathog. 8(5):e1002675 (2012).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  63. Schuerholz T, Dömming S, Hornef M, Dupont A, Kowalski I, Kaconis Y, Andrä J, Garidel P, Gutsmann T, David S, Sánchez-Gómez S, Martinez de Tejada G, and Brandenburg K, Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects, Curr Drug Targets 13(9):1131-1137 (2012).
  64. Martinez de Tejada G, Sánchez-Gómez S, Kowalski I, Kaconis Y, Andrä J, Schürholz T, Hornef M, Dupont A, Garidel P, Gutsmann T, David Sunil A, and Brandenburg K, Bacterial cell wall compounds as promising targets of antimicrobial agents, I. Antimicrobial peptides and lipopolyamines, Curr Drug Targets 13(9):1121-1130 (2012)
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  65. Schuerholz T, Brandenburg K, and Marx G, Antimicrobial peptides and their
    potential application in inflammation and sepsis, Crit. Care 16, 207 (2012).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  66. Manček-Keber M, Benčina M, Japelj B, Panter G, Andrä J, Brandenburg K, Triantafilou M, Triantafilou K and Jerala R, MARCKS as a negative regulator of LPS signaling, J. Immunol. 188(8):3893-902 (2012).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  67. Krepstakies M, Lucifora J, Nagel C.-H., Zeisel M, Holstermann B., Hohenberg H, Kowalski I, Gutsmann T, Baumert T. F., Brandenburg K, Hauber J and Protzer U. Targeting virus attachment and entry by a new class of synthetic cross-species peptide inhibitors, J. Infect. Dis. 205(11):1654-1664 (2012).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  68. Fukuoka S, Richter W, Howe J, Andrä J, Rössle M, Alexander C, Gutsmann T, and Brandenburg K. Biophysical investigations into the interactions of endotoxins with bile acids. Innate Immunity 18(2):307-217 (2012).
  69. Rappolt M, Rössle M, Kaconis Y, Howe J, Andrä J, Gutsmann T, and Brandenburg K. X-ray scattering of bacterial cell wall compounds and their neutralization , NOVA Science Publishers, pp. 133-148 (2011).
  70. Suwalsky M, Manrique-Moreno M, Howe J, Brandenburg K and Villen F. Molecular Interactions of Mefenamic Acid with Lipid Bilayers and Red Blood Cells. J. Braz. Chem. Soc. 12, 2243-2249 (2011)
  71. Jeworrek C, Evers F, Howe J, Brandenburg K, Tolan M, Winter R.
    Effects of Specific versus Nonspecific Ionic Intections on the Structure and Lateral Organization of Lipopolysaccharides. Biophys. J. 100, 2169-2177 (2011).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  72. Kaconis Y, Kowalski I, HoweJ, Brauser A, Richter W, Razquin-Olazarán I, Iñigo-Pestaña M, Garidel P, Rössle M, Martinez de Tejada G, Gutsmann T, and Brandenburg K. Biophysical mechanisms of endotoxin neutralization by and its specificity for cationic amphiphilic peptides. Biophys. J. 100, 2652-2661 (2011).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  73. Brandenburg K, Andrä J, Garidel P, and Gutsmann T. Peptide-based treatment of sepsis. Appl. Microbiol. Biotechnol. 90, 799-808(2011).
  74. Sánchez-Gómez S, Japelj B, Jerala R, Moriyón I, Alonso MF, Leiva J, Blondelle SE, Andrä J, Brandenburg K, Lohner K, Martinez de Tejada G. Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo. Antimicr. Agents Chemother. 55, 218-228 (2011).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  75. Brandenburg K, Andrä J, Gutsmann T, Howe J, and Garidel P. Isothermal titration calorimetric studies of the interaction of phosphor- and glycolipids with anti-infective agents, In: Thermal Analysis in Medical Application', Editor Denes Lörincy, Akademiai Kiado, Budapest (2011).
  76. Richter W, Vogel V, Howe J, Steiniger F, Brauser A, Koch MHJ, Roessle M,
    Gutsmann T, Garidel P, Mäntele W, Brandenburg K. Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin. Innate Immun 17, 427-438 (2011).
  77. Oliveira R, Schneck E, Quinn B, Konovalov O, Brandenburg K, Gutsmann T,
    Gill T, Hanna C, Pink D, Tanaka M. Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence X-ray structural characterizations and Monte Carlo simulations. Phys. Rev 81(4) (2010).
  78. Brandenburg K, Howe J, Sánchez-Gómez S, Garidel P, Roessle M, Andrä J, Zweytick D, Lohner K, Rappolt M, Blondelle S, Moriyon I and Martinez de Tejada G. Effective Antimicrobial and Anti-Endotoxin Activity of Cationic Peptides Based on Lactoferricin: A Biophysical and Microbiological Study. Anti-infect Agents Medicin Chem 9, 9-22 (2010).
  79. T. Gutsmann, I. Razquin-Olazarán, I. Kowalski, Yani Kaconis, J. Howe, R. Bartels, M. Hornef3; T. Schürholz, M. Rössle, S. Sanchez-Gómez, I. Moriyon, G. Martinez de Tejada, K. Brandenburg. New antiseptic peptides to protect from endotoxin-mediated shock, Antimicrob. Agents Chemother. 54, 3817-3824 (2010).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  80. Kowalski I, Kaconis Y, Andrä J, Razquin-Olazarán I, Gutsmann T, Martinez de Tejada G, and Brandenburg K, Physicochemical and biological characterization of anti-endotoxin peptides and their influence on lipidproperties; Protein Pept. Lett. 17, 1328-1333 (2010).
  81. Suomalainen M, Lobo LA, Brandenburg K, Lindner B, Virkola R, Knirel YA, Anisimov AP, Holst O, and Korkonen TK,Temperature-induced changes in the lipopolysaccharide of Yersinia pestis affect plasminogen activation by the Pla surface protease. Infect. Immun. 78: 2644-2652 (2010).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  82. Brandenburg K, Garidel P, Fukuoka S, Howe J, Koch MHJ, Gutsmann T, and Andrä J, Molecular basis for endotoxin neutralization by amphiphatic peptides derived from the alpha-helical cationic core-region of NK-lysin. Biophys. Chem. 150, 80-87 (2010).
  83. Brandenburg K, Schromm AB, and Gutsmann T. Endotoxins: Relationship between structure, function, and activity, In: Subcellular Biochemistry, Vol. 53: Endotoxins: Structure, function, and recognition, (X. Wang and P.J. Quinn, Eds.) Springer-Verlag, pp. 65-79 (2010).
  84. Schneck E, Schubert T, Konovalov OV, Quinn BE, Gutsmann T, Brandenburg K, Oliveira RG, Pink DA, and Tanaka M. Quantitative determination of ion distributions in bacterial lipopolysaccharide membranes by grazing-incidence X-ray fluorescence. Proc Natl Acad Sci U S A.107(20):9147-9151 (2010).
    Publication charge-free by Publisher / Publikation kostenlos vom Verlag erhältlich!
  85. Schromm AB, Reiling N, Howe J, Wiesmüller KH, Roessle M, and Brandenburg, K. Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis. Innate Immunity 16, 213-225 (2010).
  86. Brandenburg K. and Seydel U. Conformation and supramolecular structure of lipid A, Adv. Exp. Med. Biol. 667, 25-38 (2009)
  87. Brandenburg K., Garidel P., and Gutsmann T. Physicochemical properties of microbial glycopolymers, In: Microbial Glycobiology, (A.P. Moran, O. Holst, P.J. Brennan, M. von Itzstein, Eds.), E-book, Elsevier, pp. 759-779 (2009).
  88. 34Schneck E, Oliveira RG, Rehfeldt F, Demé B, Brandenburg K, Seydel, U, and Tanaka M. Mechanical properties of interacting lipopolysaccharide membranes from bacteria mutants studied by specular and off-specular neutron scattering. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 80(4 Pt 1).
  89. Garidel P. and Brandenburg K., Current Understanding of Polymyxin B Applications in Bacteraemia/Sepsis Therapy Prevention: Clinical, Pharmaceutical, Structural and Mechanistic Aspects, Antiinfect. Agents Medic. Chem. 8, 367-385 (2009)
  90. Kerth, A., Garidel P.,Howe J., Alexander C., Mach J.-P., Waelli T., Blume A, Rietschel E.Th., and Brandenburg K.. An infrared reflection-absorption spectroscopic (IRRAS) study of the interaction of lipid A and lipopolysaccharide Re with endotoxin-binding proteins. Medic. Chem. 6, 535-542 (2009).
  91. Brandenburg K., Howe J, Gutsmann T, and Garidel P. The expression of endotoxic activity in the Limulus test as compared to cytokine production in immune cells. Curr. Med. Chem. 16, 2653-2660 (2009).
  92. Gutsmann T, Howe J, Zähringer U, Garidel P, Schromm AB, Koch MHJ, Fujimoto, Y.,Moriyon I, Martínez-de-Tejada G, and Brandenburg K. Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells. Innate Immun. 16: 39-47 (2009).